Janoris Jenkins intercepted two passes and returned them both for touchdowns. That feat had never been accomplished by any Rams player in the team's history. Craig Dahl and James Laurinaitis also had interceptions off Cardinals rookie quarterback Ryan Lindley.
Sam Bradford threw touchdown passes to Lance Kendricks and Chris Givens to lead the Rams offense. Steven Jackson also ran for 139 yards.
With the win, the Rams raise their season record to 4-6-1. They are 3-0-1 in division play.