The 125-pound, two-year-old cub, named Boo-Boo, ran away from a traveling bear exhibit based out of Florida.
He was last seen on Tuesday.
People living in the area have been told to not approach Boo-Boo if they see him.
"If he hears a loud noise, there are concerns he may bed down a little bit further and we may not see him. So we're going to spread out a little further, add traps possibly for the night, some game cameras." said Mitts Mravic of the Florida Fish and Wildlife Conservation Commission.
The facility was recently cited for not having a proper fence for an alligator.
Boo-Boo leaves behind a brother back at the exhibit named, Yogi.