(CNN) -- A weather system stretching from Michigan to the Louisiana coastline threw down high winds and spawned a handful of tornadoes Wednesday, including one that caused significant damage in the northwest Georgia town of Adairsville.
At least two people died, authorities reported.
In the Adairsville storm, winds caused significant damage to a motel and a manufacturing plant, according to Craig Milsap, the fire chief and interim emergency management director for Bartow County. The motel's guests are believed safe and workers at the plant have all been accounted for, he said.
The National Weather Service also reported major structural damage and overturned cars in downtown Adairsville, where a news crew for CNN affiliate WSB-TV witnessed a tornado form and touch down Wednesday morning. The tornado destroyed a home and flipped several cars, the station reported.
The storm caused major damage on and near Interstate 75, the Georgia Department of Transportation said. The weather service, citing emergency management officials, said 100 cars had been overturned near Exit 306 at Adairsville.
The state transportation agency asked motorists to stay away from the area until further notice.
The weather service also reported multiple buildings damaged in Calhoun, Georgia.
One person died in Bartow County when a building collapsed during the storm, Milsap said.
In Tennessee, a 47-year-old man died early Wednesday when high winds toppled a tree onto the roof of his home in Nashville, the Tennessee Emergency Management Agency said. Other injuries were reported in Chester, McNairy and Henderson counties, spokesman Jeremy Heidt said.
The National Weather Service also reported severe weather or damage Wednesday in Texas, Mississippi, Alabama, Kentucky and Indiana.
Southeast Alabama, much of Georgia and parts of North Carolina and South Carolina were under a tornado watch through 8 p.m. ET.
Earlier, in Alabama, the storms blew the metal roof off a building in Sheffield, CNN affiliate WHNT said. The storm also damaged a church steeple in Rogersville, the station reported.
In Kentucky, winds blew off much of the roof of the Penrod Missionary Baptist Church and damaged several homes, CNN affiliate WFIE reported.
In Nashville, the weather service listed dozens of damage reports across the region: a funnel cloud was reported early Wednesday in Jackson County, there were dozens of reports of downed trees and power lines, and law enforcement reported damage to homes and businesses.
CNN affiliate WSMV also reported the partial collapse of an office building in Mount Juliet.
"I built it myself to take an event like this. And it looks like a freight train hit it," the station quoted building owner Dewey Lineberry as saying. "It's just destroyed. It laid the building down on top of cars, it put the building on top of people. It's unbelievable."
Workers who were inside the building when the storm hit took cover under mattresses, the station said.
The storm came dangerously close to WSMV, the station reported: Workers had to move to a safe room when a buzzer in the newsroom alerted them of storm danger around 4 a.m. (5 a.m. ET) Wednesday, the station reported.
In Wilson County, Tennessee, strong winds damaged four buildings, though it was not immediately known if it was the result of a tornado, Emergency Management Director John Jewell told CNN.
One family became trapped inside their mobile home and were rescued, he said.
About 14,000 people in the country were without power, Jewell added.
On Tuesday, the storms raked Arkansas, Louisiana and Mississippi, among other places, with heavy rain and high wind.
William Jones waited out the storm with his family inside their truck, CNN affiliate KFSM reported.
"We pulled over and come to stop and about the same time we stopped was when it started to cross the road about 100-150 yards ahead of us," the station quoted him as saying. "We watched it tear out all the trees, throw the debris in the road."
A large springlike storm system is pushing severe thunderstorms, damaging winds and unstable conditions favorable for tornadoes eastward through the Mississippi Valley.
Heavy gusts in excess of 70 mph could bring significant damage. "I think it's definitely a dangerous night and day," CNN meteorologist Ivan Cabrera said as the front moved in.
Flood warnings and watches speckled the weather map from Michigan to southern Louisiana. Many regions should see heavy downpours, Cabrera said, but the front is not expected to stall out and dump excessive amounts of precipitation in any particular area.
The wet weather was predicted to trigger winter storms in the northern Plains states. A freezing rain advisory is in effect for much of Iowa and Wisconsin.
By Ben Brumfield and Michael Pearson
CNN's Vivian Kuo contributed to this report.
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