The accident took place around 8:20 p.m. on Hwy 110 at Hwy P.
Several more people were injured in the accident, according to a spokesman for the Missouri State Highway Patrol.
A minivan was headed southbound on 110 when it hit an oncoming pickup hauling other vehicles.
Two people in the minivan were killed. No other injuries were reported.
The victims have not been identified, pending notification of family members.
Fox 2 News will have more information on this story as it becomes available.