The fire took place just before 1:40 a.m. in the 6100 block of Eaton Drive. Authorities have not identified the two women.
Police said 39-year-old Michael Smith lived at the home, but has gone missing. He's approximately 5'10" tall and weighs 185 pounds. His vehicle is described as a newer model Chevy Camaro, red in color, with temporary Missouri tags.
Anyone with information on Smith's whereabouts is asked to contact the Berkeley Police Department at 314-524-3311.