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UPDATE: 12:42 PM Friday: THe Missouri State Highway Patrol now says the number of people killed is at five, not six.

UPDATE: I-57 REOPENS. All lanes between I-55 and the Illinois state line have been cleared and the highway has been reopened. Continue to use caution in the area as traffic flow returns to normal. Check the Traveler Information Map for all updates:

ST. LOUIS — Six people have died after a massive chain-reaction crash involving dozens of vehicles on an interstate in southern Missouri, police confirmed.

The crash happened around 8:09 a.m. Thursday on Interstate 57 near Charleston in Mississippi County. The Missouri State Highway Patrol said there were multiple tractor-trailer crashes and fires in the northbound and southbound lanes.

More than 30 vehicles, including passenger vehicles, were involved. Those injured in the crash were taken to three different hospitals. It’s unclear how many people were hurt in total.

Late Thursday morning, the Mississippi County Sheriff’s Office warned people to stay away from the area: “PSA: do not come to Charleston for any reason until the incident is cleared! Traffic is backing up and causing unnecessary hazards.”

The interstate remains closed near the crash site, which extends to the Missouri-Illinois state line.