Firefighters responded before 8 a.m. to the home on Crowned Court in Nash County.
The 61-year-old woman, identified by WNCN as Belinda Coble, was using the oxygen tank while she smoked a cigarette, according to the Nash County Sheriff’s Office.
The sound of the explosion and smoke alarm woke her husband, who was sleeping in a different room. The husband reportedly extinguished the fire and called 911.
Authorities found Coble dead inside the home.